Metformin is one of the most common medicines for type 2 diabetes and for conditions like PCOS. If you’re starting it or adjusting your dose, the basics below will help you understand how clinicians usually prescribe it and what to watch for.
Most people begin with 500 mg once daily with food or 500 mg twice daily (morning and evening). That reduces stomach upset. Your provider often increases the dose every 1–2 weeks — commonly by 500 mg at a time — until blood sugar targets are met or side effects limit higher doses.
Typical effective dose ranges are 1,500–2,000 mg per day. Many doctors cap immediate‑release metformin at 2,000 mg/day. Some regimens use higher totals (up to ~2,500–2,550 mg/day) but that’s done under close supervision and isn’t the routine approach.
If GI side effects (nausea, diarrhea, bloating) appear, options include slower titration, taking metformin with a full meal, switching to an extended‑release (ER) form, or splitting the dose. ER tablets often cause fewer stomach problems and should not be crushed or chewed.
Kidney function matters. Most guidelines say don’t start metformin if your eGFR is below 30 mL/min/1.73 m². If eGFR is between 30–45, doctors usually lower the dose and monitor kidney tests more often. If your kidney function drops while you’re taking metformin, your provider may reduce the dose or stop it.
Tell your care team before any procedure using iodinated contrast dye — many clinics advise holding metformin around the time of the scan if you have reduced kidney function. Also avoid heavy alcohol use; that raises the small but serious risk of lactic acidosis.
Other checks: hemoglobin A1c to track glucose control, and periodic vitamin B12 testing if you’ve been on metformin for a long time or have numbness/tingling. Drug interactions to mention to your provider include cimetidine and some heart medicines — your pharmacist can run a quick check.
If you miss a dose, take it with your next meal. Don’t double up to make up for a missed pill. Pregnant or breastfeeding? Talk to your doctor — metformin is used in some pregnancies, but that should be managed by a clinician.
Bottom line: start low, go slow, take with food, and keep an eye on kidney tests and B12. If stomach problems or other questions come up, ask your prescriber about switching to ER or adjusting how quickly the dose is increased.
Metformin is a widely prescribed medication for managing type 2 diabetes, known for its effectiveness and affordability. Understanding its effects, interactions, and dosage is crucial for safe use. This article offers insights into where to find the best deals on Metformin and tips on purchasing it safely. Navigate the world of diabetes care with confidence, ensuring both health and budget are prioritized.
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